Archive for December, 2007

Cancer conflict

Dee Lewis on Dec 19th 2007

Cancer conflict

 
 

BY SHAWN A. HESSINGER
STAFF WRITER
shessinger@republicanherald.com

 
 

12/08/2007

 
 

Officials abruptly backpedaled on a federally funded health study that suggests an environmental link to a cluster of the disease in northeastern Pennsylvania, saying an abstract that made the claim was mistakenly released to the public.

“The bottom line is that the abstract you’re reading conflicts with the information we released in October,” said Steve Dearwent, chief of the investigations branch, Division of Health Studies for the Agency on Toxic Substances and Disease Registry.

The report for an upcoming presentation at a national medical conference Monday says residents living within 13 miles of the former McAdoo Associates Superfund site, Kline Township, had a 4 1/2 times greater likelihood of developing polycythemia vera than others during the 15 years that include the site’s operation and cleanup.

The research is to the presented Monday at a medical conference in Atlanta. An abstract released in advance of the meeting said there is “significant evidence” that something in the environment caused an unusually large number of cases of polycythemia vera in Luzerne, Carbon and Schuylkill counties.

However, Dearwent said Friday the abstract prepared for the American Society of Hematology was assembled in August or September before data had been further reviewed by senior ATSDR officials and representatives of the Pennsylvania Department of Health.

During the initial complication of data, Dearwent said investigators may have “injected bias” into the report by placing too much significance on resident with the disease who had lived within close proximity to McAdoo Associates without considering that many had lived in upper to five or six locations as well.

However, federal officials do not deny that 18 out of 38 confirmed cases of the illness, or 49 percent, occurred in residents who lived witht 13 miles of the former Superfund site between 1970 and 1995.

Dearwent said additional research might prove an environmental link. And the study’s lead researcher, Dr. Ronald Hoffman of the Mount Sinai School of Medicine in New York, said Friday that the data does in fact point to something in the environment.

“Based upon the data, there’s significant concern that there is something in the environment leading to the development of polycythemia vera in the area. The nature of what’s causing it is unknown at the moment and is going to require further study,” he said.

At an Oct. 24 meeting in Hazleton, data released by the agency showed elevated levels of the rare blood disease, but was not specific about where cases were concentrated and made no link with the environment. Federal officials defended their lack of ability to link the illness to environmental factors to the disgust of an angry crowd of more than 130 people.

U.S. Rep. Tim Holden admitted some confusing over contradictory results between the October meeting and the latest report.

“Don’t ask me to answer any questions because I don’t know any more than you,” Holden said Friday.

He said he is working with U.S. Sen. Arlen Specter’s office in an effort to set up a meeting with federal health officials to discuss the seemingly contradictory data.

Kendra Barkoff, a spokeswoman for U.S. Sen. Robert Casey, echoed Holden’s concern.

“We definitely are well aware of the problem and we are working with Sen. Specter’s office. We’re reaching out to local environmental and medical people to see what we can do,” Barkoff said.

Specter’s office forwarded a copy of a letter from Specter, Casey and Holden expressing concern over the release of the abstract and urging officials to make clarificiations.

Specter had called for the intial investigation by the ATSDR.

Dante Picciano, a lawyer and geneticist who is active in local environmental issues said the data indicate a much larger problem than polycythemia vera. He wants a study of a wide range of cancers and other diseases in the region.

“This is the tip of the iceberg. It’s inconceivable that you’re going to have environmental exposures cause an increase in (only) one type of rare cancer,” he said.

Polycythemia vera, classified as cancer, can lead to heart attack or stroke. About one case of polycythemia vera occurs each year in every 100,000 Americans. The cause is unknown.

Local activists have raised suspicions about McAdoo Associates, where a hazardous waste recycling business operated from 1975 to 1979 and accepted hundreds of thousands of gallons of paint sludge, waste oils, used solvents, PCBs and many other known or suspected carcinogens.

Environmental officials shut down the site in 1979, and it was later placed on the federal Superfund list and cleaned up.


http://www.zwire.com/site/news.cfm?newsid=19097858&BRD=2626&PAG=461&dept_id=529074&rfi=6
(The Associated Press contributed to this report.)

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Feds back off disease report.

Dee Lewis on Dec 19th 2007

* Note last paragraph:

 
 

 
 

Feds back off disease report. The Agency for Toxic Substances and Disease Registry has now backed off the abstract of a report concerning diseases that may have been caused by illegal dumping at a Kline Township site in the 1970s. Hazleton Standard-Speaker, Pennsylvania. 8 December 2007.

 
 

http://www.standardspeaker.com/index.php?option=com_content&task=view&id=6385&Itemid=2

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Broad Agency Announcement for Conferences, Workshops, and/or Meetings

Dee Lewis on Dec 19th 2007

Broad Agency Announcement for Conferences, Workshops, and/or Meetings


URL: http://es.epa.gov/ncer/rfa/2008/2008_baa.html

Open Date: 12/04/2007  -  Close Date: 12/09/2008

Summary: The U.S. Environmental Protection Agency (EPA) is issuing this
Broad Agency Announcement (BAA) soliciting applications from eligible
applicants for
the planning, arranging, administering and/or conducting of conferences,
workshops, and/or meetings (hereinafter referred to as “conferences”)
that focus on research to protect human health and safeguard the
environment. Specifically, EPA is interested in supporting scientific
and technical research conferences that address the following research
program areas: (1) human health; (2) ecosystems; water and security; (3)
economics and sustainability; (4) air and global climate change; and (5)
technology.


This BAA is open from December 10, 2007 through December 9, 2008.
Applications must be received by January 7, 2008; June 5, 2008; and
December
9, 2008 depending upon the cycle (as identified in Section II of this
BAA) for which the applicant is requesting funding.

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Feds hedge on environmental link to Pennsylvania illnesses

Dee Lewis on Dec 8th 2007

12/7/2007, 4:32 p.m. ESTBy MIKE STOBBE and MICHAEL RUBINKAM

The Associated Press

 

ATLANTA (AP) — Officials abruptly backpedaled Friday on a federally funded health study that suggests an environmental link to a cluster of rare blood cancer cases in northeastern Pennsylvania, saying an abstract that made the claim was mistakenly released to the public.The research is to be presented Monday at a medical conference in Atlanta. An abstract released in advance of the meeting said there is “significant evidence” that something in the environment caused an unusually large number of cases of polycythemia (pah-lee-sy-THEE’-mee-ah) vera in Luzerne, Carbon and Schuylkill counties.

The abstract, which was submitted to the American Society of Hematology, also said that people who had lived within 13 miles of a former toxic waste dump in northern Schuylkill County developed the blood cancer at a rate 4.5 times higher than people living in other parts of the three counties.

Steve Dearwent, a government epidemiologist, said Friday that the abstract was written early in the summer and that subsequent analysis of the data did not support the conclusion of an environmental link — although he added that still is a possibility. He said the abstract should have been revised before it was submitted. Continue Reading »

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Evidence for an Environmental Influence Leading to the Development of JAK2V617F-Positive Polycythemia Vera: A Molecular Epidemiological Study

Dee Lewis on Dec 7th 2007

TITLE:  Evidence for an Environmental Influence Leading to the

Development of JAK2V617F-Positive Polycythemia Vera: A Molecular Epidemiological Study.

Below is a copy of the ATSDR’s abstract to be presented at the American Society of Hematology meeting on December 10 in Atlanta. The ATSDR investigation identified a total of 131 possible PV cases, including 97 state cancer registry and 34 self-reported cases, of which 72 agreed to be interviewed and 63 were tested for JAK2V617F.

A spatial scan statistical analysis identified this area as a significant cluster and individuals living within this area had a 4.5 times greater risk of developing PV compared to individuals residing in the remainder of the 3 counties (p<0.001).4 cases of JAK2V617F+ PV were identified within the described area along a 2-mile stretch of a single street containing 70 homes, including 2 individuals who lived in the same dwelling.

The lack of traditional epidemiological explanations and the high degree of statistical certainty for the geographical association of the cases strongly suggests that an external influence led to the development of PV. 

[264] Evidence for an Environmental Influence Leading to the Development of JAK2V617F-Positive Polycythemia Vera: A Molecular Epidemiological Study. Session Type: Oral Session Ronald Hoffman, Mingjiang Xu, Paul I. Roda, Aisha Jumaan, Brian Lewis, Carol A. Gotway, Vincent Seaman Mount Sinai School of Medicine and MPD Research Alliance 

 Consortium, New York, NY, USA; North Eastern Medical Oncology, Hazelton, PA, USA; The Agency for Toxic Substances of Disease Registry, Atlanta, GA, USA; Centers for Disease Control 

 Prevention, Atlanta, GA, USA; University of Illinois, Chicago, IL, USAPolycythema vera (PV) is a chronic myeloproliferative disorder (MPD) associated with an acquired mutation (JAK2V617F) in over 90% of patients. The incidence of PV in the US, based on national cancer registry data from 2001-03, is 0.9 persons/105population/year. In Oct. 2006, the PA Dept. of Health requested the assistance of the Agency for Toxic Substances and Disease Registry (ATSDR) in confirming a suspected cluster of PV in the 3 counties (Carbon, Luzerne, 

Schuylkill) surrounding the borough of Tamaqua, home to multiple Superfund and National Priorities Listing sites. These counties have a total population of 527,000 individuals. The ATSDR investigation identified a total of 131 possible PV cases, including 97 state cancer registry and 34 self-reported cases, of which 72 agreed to be interviewed and 63 were tested for JAK2V617F. The PV diagnosis was confirmed in 38 of the interviewed participants (53%) based on a JAK2V617F+ assay with granulocytes (37 cases) or a JAK2V617F- assay but satisfying WHO criteria for the diagnosis of PV (1 case). Of the 37 cases who met both clinical and molecular criteria (JAK2V617F+) for a diagnosis of PV, 18 (49%) had resided within a 13 mile radius of the McAdoo Associates Superfund Site (MASS) for >5 years during the period 1970-95. The MASS was the home of a hazardous waste recycling business from 1975-79 where large quantities of toxic chemicals were dumped directly into old mine shafts.The Environmental Protection Agency completed surface remediation in the early

90s, but was unable to determine the extent and fate of the chemicals poured into the mine. A spatial scan statistical analysis identified this area as a significant cluster and individuals living within this area had a 4.5 times greater risk of developing PV compared to individuals residing in the remainder of the 3 counties (p<0.001). 4 cases of JAK2V617F+ PV were identified within the described area along a 2-mile stretch of a single street containing 70 homes, including 2 individuals who lived in the same dwelling. No familial inheritance patterns of PV were documented, nor were any correlations noted with regards to type of employment or recreational/leisure activities. The lack of traditional epidemiological explanations and the high degree of statistical certainty for the geographical association of the cases strongly suggests that an external influence led to the development of PV. Since the PV rates are based on both self-identified and cancer registry cases, direct comparisons to state and national rates can t be made. Continue Reading »

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Feds: Data ‘strongly suggests’ rare cancer tied to environment

Dee Lewis on Dec 7th 2007

Feds: Data ’strongly suggests’ rare cancer tied to environment

BY KENT JACKSON
AND SHAWN A. HESSINGER
TIMES • SHAMROCK WriterS
kent.jackson@standardspeaker.com
shessinger@republicanherald.com

12/07/2007

In a surprising declaration, the federal government says there is “significant evidence” that people living near the McAdoo Associates Superfund site face an extra risk of developing a rare blood cancer due to environmental factors, according to a document posted on the American Society of Hematology Web site Thursday.The report by the Agency for Toxic Substances and Disease Registry for the first time draws a link between the environment and polycythemia vera only six weeks after the same agency claimed no such link could be found. Continue Reading »

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TCE suit on track, despite setback

Dee Lewis on Dec 4th 2007

TCE suit on track, despite setback

Costly fight ‘is worth the wait,’ advocate says

By Tom Wilber
Press & Sun-Bulletin

Post Comment

ENDICOTT — Lawyers and their clients claiming damages from IBM pollution said they are disappointed after nearly four years of settlement talks proved fruitless, but they are confident they will prevail after the case goes to court.

IBM representatives would not comment on the case, but based on IBM’s final offer — less than 3 percent of plaintiffs’ claims — company lawyers also like their chances in court.

IBM offered $3 million to settle more than $100 million in health and property claims related to pollution from the company’s former microelectronics plant on North Street, effectively ending negotiations this month as plaintiffs prepare to file a lawsuit in January.

All involved in the case can expect an expensive and exhausting fight likely to last years longer as the case enters a new phase, said David Driesen, a professor at Syracuse University Law School.

Bernadette Patrick, a client and advocate who was among the first to organize affected residents after the problem was discovered in 2003, is prepared for an extensive fight.

“The bottom line is, we want some kind of resolution. Not a quick fix,” she said. “It’s not just about attorneys coming here and making a lot of noise.”

If the case is decided in a trial, those attorneys will be spending a lot of money. In toxic tort cases like this one, plaintiffs’ attorneys fund their own work and take their pay at the end from any awards their clients win.

Stephen G. Schwarz, a lawyer with the Rochester firm of Faraci & Lange, would not say how much legal teams from five law firms have collectively invested in the case since they began signing on clients in 2003. But it’s “a drop in the bucket” compared to the cost of bringing the case to trial, he said.

Driesen, who is not involved in the IBM case, added that large corporations with deep pockets can take legal strategies designed to prolong the case and wear down opponents.

“It’s pretty common for companies to throw a lot of resources (into the case) to create a lot of work for the plaintiffs,” he said.

The claims, from nearly 1,000 clients, stem from a subterranean plume of trichloroethylene (TCE) found to be creating vapors wafting into more than 480 homes and buildings near the plant. Exposure to the chemical is linked to illnesses ranging from cancer to brain damage, but the amount posing calculable risks is debatable.

In 2005, state health officials documented an unexplained elevation of certain cancers and birth defects in areas affected by pollution south and southwest of the plant.

The process that allows each side to gather information to build their cases, called discovery, can take years in a case involving the size and complexity of the IBM pollution case. During discovery, the plaintiffs will get access to IBM records and witnesses to gain a better understanding of the pollution, including how it got there, when and what IBM knew about it.

The defendants typically gather exhaustive health histories on people making claims in an effort to prove their illnesses could be caused by other things.

As this process unfolds, information may come to light that brings the two sides back to the negotiating table.

“As they get to know each other, it can narrow the gaps between their perceptions and what the case is worth,” Driesen said.

Patrick — who unknowingly lived in the polluted area as she raised a daughter who developed Hodgkin’s disease at the age of 17 — said the IBM settlement offer falls way short.

“It deserves so much more than that, and it is worth the wait,” she said.

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Scientist: Chemical may be more toxic than officials think

Dee Lewis on Dec 4th 2007

Scientist: Chemical may be more toxic than officials think

By Tim Damos


A toxic and potentially cancer-causing chemical dumped at a Baraboo Army Ammunition Plant years ago could be more dangerous than federal and state officials think, one scientist warns.

Wisconsin might become the first state to set groundwater standards for certain forms of a chemical known as DNT that was used by the Army to manufacture explosives. Army officials say state regulators are being overly cautious, and a local environmental group says Wisconsin is on the right track.

“Hopefully, (the Army) can be adult about this and recognize there is a problem that resulted from their activities,” said Dr. Peter deFur, a scientific consultant hired by the nonprofit group Citizens for Safe Water Around Badger. “They should clean up after themselves.”

The Badger Army Ammunition Plant south of Baraboo was operational during conflicts from World War II through the Vietnam War. Clean-up efforts at the 7,000-acre plant, built in 1942, have been under way since the Army said the plant would no longer be needed in 1995.

DNT attacks the cardiovascular, nervous and reproductive systems and can cause headaches, fatigue, nausea, vomiting and chest pain, according to a state toxicologist’s report. Some studies suggest it may cause cancer.

DNR reports show that all forms of the chemical have been found in groundwater from the base of the Baraboo bluffs to Prairie du Sac.

The state has a groundwater standard for two forms of DNT, which guide the Army’s clean-up efforts. The other four forms — which aren’t regulated — only made up a small portion of what was used to make explosives. But they have been found in greater proportions in monitoring wells in and around Badger, suggesting they aren’t breaking down as quickly as the regulated types of DNT, deFur said.

“The more toxic forms are the ones that hang around the longest,” he said.

In May, the Wisconsin Department of Natural Resources asked state public health specialists to set temporary guidelines for the four unregulated forms of DNT, for which there are no state or federal standards.

A state toxicologist suggested the DNR limit the total concentration of all six forms of DNT to .05 parts per billion, which would be stricter than current standards. The DNR accepted the findings and set an interim drinking water health advisory.

An Army toxicologist disagreed with the state’s findings, saying there hasn’t been enough research on the unregulated forms of DNT to justify a health advisory.

“That’s a hollow argument, in my estimation,” deFur said. “Because it claims ignorance is an excuse for not protecting people.”

There’s no telling what DNT might do to small children, deFur said, because the data just isn’t available.

Army toxicologist Emily May LaFiandra directed the News Republic’s questions to an Army spokeswoman.

“We are advising our client, Badger, that we believe more studies need to be done to reach a clear scientific answer about human health effects (of the unregulated forms of DNT),” U.S. Army Center for Health Promotion & Preventive Medicine spokeswoman and public affairs officer Lyn Kukral said in an e-mail. “However, we are recognizing that the responsibility for determining a standard and enacting it belongs to the state of Wisconsin.”

The Army toxicologist used old data to reach her conclusion, deFur said, and the state should set even tougher standards than the interim advisory they have now.

Kukral didn’t respond specifically to deFur’s comments, which also were sent to state public health officials on behalf of Citizens for Safe Water Around Badger.

The DNR is beginning the process of setting a permanent groundwater standard for all forms of DNT. It will seek input from interested parties before setting a standard that will be approved by state lawmakers.

If a standard is set next year, it could influence other states to do the same, said Laura Olah, director of Citizens for Safe Water Around Badger. That could mean more headaches for Army officials trying to get sites deemed clean.

She said the action taken by the DNR is the result of unusually strict groundwater testing around the plant.

“Badger is the only plant we know of that’s testing the four less-common forms of DNT,” she said. “Unfortunately, Badger is just one of the Army plants that has this contamination.”

http://www.wiscnews.com/bnr/news/259764

Laura Olah, Executive Director

Citizens for Safe Water Around Badger

E12629 Weigand’s Bay South

Merrimac, WI  53561

(608)643-3124

Email: info@cswab.org

Website: www.cswab.org

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How safe is water from the tap?

Dee Lewis on Dec 4th 2007

How safe is water from the tap?

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Although chemical pollutants had tainted parts of Southern California groundwater, the drinking water is free of solvents.

By Mary Beckman, Special to The Times
December 3, 2007

FOR years before the mid-1980s, groundwater in parts of Southern California was contaminated with toxic solvents, yet the federal body responsible for tracking this didn’t investigate the potential health threat to people who were drinking contaminated tap water. A congressional committee is now investigating why that neglect occurred.

Here’s a closer look at what scientists know about the main solvents of concern and their health effects.


Drinking water safety

Trichloroethylene (TCE) and the related compound tetrachloroethylene, also known as perchloroethylene (PCE or PERC), are industrial solvents still used to clean up grease and to dry-clean clothes. For a long time, their use was unregulated and many companies across the nation disposed of them in such a way that they leached into drinking water sources.

In 1980, the Environmental Protection Agency started a Superfund project to clean up a variety of chemical pollutants. The effort includes getting the perpetrators of improper TCE and PCE disposal, many of them defense contractors, to help remove the worst of the contamination across the country.

What problems do these closely related solvents cause?

Scientists know that TCE can cause cancer — usually of the kidneys, liver and lungs — at high doses. They have concluded this from studies on animals that were given contaminated water to drink, as well as from people exposed to TCE through their work or through contaminated drinking water.

They don’t yet understand how TCE causes cancer: Researchers studying the question say the process is pretty complicated, and the jury is still out on the exact mechanism.

Peter Preuss, director of the EPA’s National Center for Environmental Assessment, says that TCE breaks down into several different components, some of which are carcinogenic. “There are maybe three to five routes by which TCE might induce cancer,” he says.

But the cancer data are from animal and humans subjected to high doses of TCE. To understand what might happen at lower doses found in the environment, researchers have to extrapolate.

“There’s a fair amount of uncertainty,” Preuss says. And the kinds of new experiments that are needed to determine whether the levels found in Southern California water led to cancer are difficult to do. Preuss is leading an effort to determine what health effects the TCE might have had over the years by examining all the available, published data.

What about PCE?

Some of the best data on the health effects of these solvents come from Marines based at Camp Lejeune in North Carolina from November 1957 through February 1987. Those who lived in the base’s Tarawa Terrace family housing units drank water contaminated with PCE from a dry-cleaning operation near the water source.

Researchers with the Agency for Toxic Substances and Disease Registry — a group within the Centers for Disease Control and Prevention concerned with toxic chemicals — estimate that in 1985 the PCE in groundwater was at a concentration of approximately 800-1500 parts per billion. That’s far above the 5 ppb limit the EPA considers safe.

Over time, PCE breaks down into TCE; the researchers estimated that levels of TCE, which is subject to the same 5-ppb limit as PCE, were as high as 100 ppb.

The Marines drank considerably less of the solvents than were present in the groundwater, however. The water coming out of the water treatment plant contained about 200 ppb of PCE and up to 15 ppb of TCE.

The Camp Lejeune study found that older mothers (35 and older) and mothers who had a history of miscarriages generally gave birth to lower-weight babies than unexposed women. The Agency for Toxic Substances and Disease Registry is continuing to look at possible birth defects and childhood cancers linked to the exposures.

Should Southern Californians be drinking bottled water?

Researchers and the EPA say there’s no need, because even with the contamination, people in Southern California are drinking solvent-free water.

Not all water sources in the L.A. area are contaminated. Also, although not all of the groundwater in regions of concern in the L.A. area have been treated to contain less than the federal limit of 5 parts per billion, what comes out of your tap is not the same as what’s in the groundwater.

The treatment systems that clean up water before it reaches people’s faucets clear out the TCE, says EPA Superfund project manager David Stensby, who oversees water treatment in one of the Superfund sites, in Glendale.

The first treatment consists of blowing air through the water. Because TCE is volatile, it catches a ride on the air, and that removes about 98% of the TCE.

The water then flows through activated carbon filters, which removes the remaining solvent. Because the carbon filters can fill up just like carbon filters on home water filtration systems can, the water is checked at various points in the process to make sure there is no TCE.

“Our performance standard is zero, not at the end of the pipe, but before the last carbon filter,” Stensby says. He adds that the TCE-filled air also goes through carbon filters before it is released: “The TCE is captured one way or another.”

The groundwater being treated this way wasn’t being used before treatment. The EPA treatment systems were put in place when cities wanted to use the water from a contaminated source.

In parts of the L.A. area not covered by the Superfund effort, water is subject to the equally strict standards set out by the California Department of Public Health.

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DEC shows Victor 3 cleanup options

Dee Lewis on Dec 1st 2007

DEC shows Victor 3 cleanup options

 

Steve Orr
Staff writer



November 29, 2007 3:08 am — Three interim cleanup options for contaminated groundwater in a part of western Victor were outlined Wednesday for citizens who trickled into public sessions held by state officials.

State environmental officials will select one of the options, all of which would cost more than $1 million to implement, early next year. If all went as planned, actual cleanup work could begin in mid- to late 2008, said Jason Pelton, state Department of Environmental Conservation project manager for the Victor site.

The cleanup techniques are intended to reduce concentrations of industrial solvents, including trichloroethene, or TCE, that were first found in groundwater in 1990. The continuing presence of TCE there has provoked an uproar in parts of the Ontario County town this year.

The DEC called the public sessions at Victor Town Hall so citizens could ask questions one-on-one. Fewer than a half-dozen people stopped by during the first two hours Wednesday. The sessions continue this morning.

State officials said they will slightly expand testing this coming winter for the presence of TCE vapors, which can rise from the tainted groundwater through the soil. Sixty-four homes were tested this year, with TCE found in high enough levels in six of them that the DEC installed special ventilation systems. As a precaution, seven more homes, on the fringe of the area where houses have already been tested, will be checked this coming winter, Pelton said.

The three cleanup options cited at the sessions were:

? Installing a permeable underground barrier that would intercept the flow of tainted groundwater and remove the solvents or break down the solvents.

? Injecting “bioremedial” micro-organisms such as bacteria into the groundwater, where they break down the solvents into harmless constituents.

? Extracting solvent vapors from under the ground after injecting air to enhance the process.

Pelton said the public will have an opportunity to comment on the interim plan after DEC has chosen its preferred option. The agency has said it will have a final cleanup plan — which could call for continued use of the interim measure — in 2009.

SORR@DemocratandChronicle.com

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